COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRUVIC ACID AND RELATED PRODUCTS USING DYNAMIC METABOLIC CONTROL

摘要

The present disclosure is related to genetically engineered microbial strains and related bioprocesses for the production of pyruvate and related products. Specifically, the use of dynamically controlled synthetic metabolic valves to reduce the activity of enzymes known to contribute to pyruvate synthesis, leads to increased pyruvate production in a two-stage process rather than a decrease in production.