SYSTEM FOR STABILISING HUMAN INTESTINAL MICROBIOTA

摘要

The present invention relates to a system comprising compositions and methods for obtaining, stabilising and applying an ex vivo model of gastrointestinal microbiota for use, for example, in the simulation of digestive processes, wherein the inclusion of the stabilised microbiota allows the carrying out of a wide range of studies on populations of microorganisms from donors belonging to a group of interest, according to a characteristic or condition related to age, gender, genotype/phenotype, ethnicity or race, or geographical location, or in relation to a specific change in the state of health, for example, caused by pathogens, nutritional aspects, obesity, renal insufficiency, metabolic disorders, etc. The stabilised microbiota, according to the present invention, can also come from a particular individual, for use in simulations of digestive processes to test therapies related to the formation of metabolites and the impact that they can have on the intestinal microbiota, for example, in cases of inflammatory bowel disease.