SELECTIVE PRESENILIN-2 GAMMA-SECRETASE INHIBITORS

摘要

The present invention relates to selective presenilin-2 γ-secretase inhibitors for use in the treatment of various diseases associated with a defect leading to Notch receptor hyperactivity. In particular the present invention relates to selective presenilin-2 γ-secretase inhibitors for use as a highly selective anti-cancer treatment. Preferred selective presenilin-2 γ-secretase inhibitors include small molecules, like 4- aminoquinolines or imidazole compounds, (monoclonal) antibodies and known γ-secretase inhibitors or analogues and combinations thereof.