Synthesis method for producing enantiomerically pure cis-imidazoline compounds for pharmaceutical use

摘要

Disclosed is a method for enantioselective synthesis of cis-imidazolines and related structures through chiral resolution. A chiral acid is used to separate enantiomeric precursors of the cis-imidazolines from a racemic mixture by selective crystallization. Both enantiomers can be cyclized into the desired cis-imidazoline by complementary pathways. Compounds can be synthesized with an enantiomeric excess as high as 99％ and may be used for treating cancer, killing senescent cells, or treating senescence-associated conditions.