Compositions, packaged pharmaceuticals, and methods of using posaconazole for the sensitization of resistant tumors

摘要

Compositions, packaged pharmaceuticals, and methods of treatment by the sensitization of resistant tumors are provided. The compositions comprise posaconazole and a chemotherapeutic agent. Tumor cells in mammalian subjects treated with posaconazole are sensitized to the effects of the chemotherapeutic agent, thus increasing the therapeutic index of the agent and reducing toxicity to the subject.