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Companion diagnostic for NSAIDs and donepezil for treating specific subpopulations of patients suffering from alzheimer's disease
Companion diagnostic for NSAIDs and donepezil for treating specific subpopulations of patients suffering from alzheimer's disease
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机译:NSAID和多奈哌齐的伴随诊断剂,用于治疗阿尔茨海默氏病患者的特定亚群
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摘要
The present invention includes a method for identifying a patient response to treatment for Alzheimer's Disease with a non-steroidal anti-inflammatory drug (NSAID) or an acetylcholinesterase (AChE) inhibitor drug comprising: obtaining a blood or serum sample from the patient; determining the presence of a proinflammatory endophenotype in the blood or serum sample of the patient; using the proinflammatory endophenotype to detect treatment response (a responder, a stable, a non-responder or an adverse responder); and treating the patient with the NSAID or the AChE inhibitor if the patient is in the responder or the stable treatment response phenotype group; or preventing a treatment with the NSAID or the AChE inhibitor if the patient is a non-responder or an adverse responder.
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