MASSIVELY PARALLEL MICROFLUIDIC CELL ANALYZER FOR HIGH THROUGHPUT MECHANOPHENOTYPING

摘要

A microfluidic device may include an inlet, an outlet, first and second channels arranged in parallel, a first sensor pair positioned along the first channel, and a second sensor pair positioned along the second channel. The first channel may include a first upstream zone, a first downstream zone, and a first constriction zone. The second channel may include a second upstream zone, a second downstream zone, and a second constriction zone. The first sensor pair may include a first entry sensor configured to detect a first cell flowing through the first upstream zone, and a first exit sensor configured to detect the first cell flowing through the first downstream zone. The second sensor pair may include a second entry sensor configured to detect a second cell flowing through the second upstream zone, and a second exit sensor configured to detect the second cell flowing through the second downstream zone.