NOVEL USE OF EXTRACELLULAR VESICLES DERIVED FROM STEM CELLS IN WHICH SOD3 IS OVEREXPRESSED

摘要

The present invention relates to a pharmaceutical composition for preventing or treating atopic dermatitis comprising, as an active ingredient, extracellular vesicles derived from stem cells in which superoxide dismutase 3 (SOD3) is overexpressed. A composition according to the present invention exhibits the effects of treating atopic dermatitis by inhibiting the proliferation of immune cells which secrete pro-inflammatory cytokines and a Treg-inducing effect, and exhibits the effects of inhibiting the infiltration of lesions of mast cells and inhibiting Th1 differentiation, and thus, can be effectively used for preventing the chronicity of atopic dermatitis or treating chronic atopic dermatitis.