OPTIONALLY NITROGENATED ISOQUINOLIN-1(2H)-ONES AND 1H-ISOCHROMEN- 1-ONES FOR TREATING PAIN AND PAIN RELATED CONDITIONS

摘要

The present invention relates to new compounds that show pharmacological activity towards the subunit α28 of voltage-gated calcium channels (VGCC), especially the α28 1 subunit of voltage-gated calcium channels or dual activity towards the subunit α28 of voltage-gated calcium channels (VGCC), especially the α28-1 subunit of voltage-gated calcium channels, and the μ-opiod receptor (MOR or mu-opioid). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.