METHODS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES USING MODULATORS OF PHOSPHOGLYCERATE KINASE 1 (PGK1) ACTIVITY

摘要

Disclosed are methods and compositions for treating and/or preventing neurodegenerative diseases or disorders in a subject in need thereof. The methods may include administering to the subject a pharmaceutical composition comprising an effective amount of a therapeutic agent that binds and/or activates phosphoglycerate kinase 1 (PGK1). Neurodegenerative diseases or disorders treated by the disclosed methods may include Parkinson-s disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and/or Lewy body dementia.