SILICA HYDROGEL COMPOSITION COMPRISING GOSERELIN FOR SUBCUTANEOUS INJECTION WITH SUSTAINED RELEASE AND SLOW RELEASE PROPERTIES

摘要

The present invention relates to a silica hydrogel composition comprising goserelin and, more specifically, to a silica hydrogel composition of goserelin with sustained release and slow release properties which can be injected by a 25G injection needle without water for injection so that the convenience in administration is improved and the initial burst release is suppressed, thereby being capable of maintaining the medicinal effect for a long period when being injected once. The silica hydrogel composition comprising goserelin according to the present invention exhibits stable drug release properties (sustained release properties) for a long period since the initial burst release is remarkably reduced (compared to the conventional controlled-release system for polymer microparticles), and thus can maintain goserelin at an effective concentration in the blood for 4 weeks or longer (slow release properties).