¹⁸F-PET/CT TRACER COMPRISING 7-DEAZAADENINE BASE AS PARENT NUCLEUS AND PREPARATION METHOD THEREFOR

摘要

Disclosed in the present invention are an ¹⁸F-PET/CT tracer comprising 7-deazaadenine base as a parent nucleus and a preparation method therefor. Disclosed in the present invention are a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein R₁ and R₂ are each independently selected from H or C₁-C₅ alkyl; and X is independently selected from ¹¹C, ¹⁸F, ¹⁵O or ¹³N. Also disclosed in the present invention are a preparation method for and use of the compound represented by formula I. The present invention successfully prepares an ¹⁸F-PET/CT tracer comprising 7-deazaadenine base as a parent nucleus: ¹⁸F-HX tracer. Experimental results show that the ¹⁸F-HX tracer prepared in the present invention can be taken up stably in tumors, which is three times higher than that in muscle tissue. Thus, the ¹⁸F-PET/CT tracer of the present invention is desirably applied to PET/CT imaging, and changes the situation wherein there is a lack of tracers for lung cancer. (I)