PROGNOSTIC MARKERS IN LUNG CANCER, PROGNOSTIC TYPING MODEL OF LUNG CANCER, AND APPLICATION THEREOF

摘要

Provided in the present application are prognostic markers in lung cancer, a prognostic typing model of lung cancer, and application thereof. The markers include imprinted genes Dcn, Peg10, Snrpn/Snurf and Trappc9. The four imprinted genes Dcn, Peg10, Snrpn/Snurf and Trappc9 of the present application have a significant correlation with prognosis of lung cancer. The imprinted gene Dcn is the most sensitive and specific marker of prognosis of lung cancer, which precedes clinicopathological features. A prognostic typing model of lung cancer can be constructed using the product of a total expression amount and a copy number variation expression amount of the four imprinted genes. The prognostic typing model of lung cancer can be used for personalized prediction of five-year survival time of lung cancer patients to provide accurate and useful prognostic information for the lung cancer patients.