MARKER USED TO DETECT INVASIVE BLADDER CANCER, AND APPLICATION THEREOF

摘要

Provided in the present application are a marker used to detect invasive bladder cancer and an application thereof, the marker being imprinted gene Grb10 and/or imprinted gene Diras3. The marker of the present application may accurately detect invasiveness of bladder cancer, having a guiding function for selecting a bladder cancer surgical means, and may decrease post-surgical recurrence and metastasis. The detection method of the present application is distinct from an immunohistochemistry method, decreasing false positive and other adverse effects; furthermore, by means of a targeted drug or technical solution for a gene silencing, knockout or rearrangement caused by a discovered imprinted gene deletion point relevant to bladder cancer invasiveness, the present application may be used to guide follow-up treatment and medication.