Changes of oncogene DKK2 and SPOCK1 expression in bladder cancer lesions and their correlation with cancer cell proliferation and invasion

摘要

Objective: To investigate the changes of oncogene Dickkopf 2 (DKK2) and sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 (SPOCK1) expression in bladder cancer lesions and their correlation with cancer cell proliferation and invasion. Methods: The bladder cancer lesions and paracancerous lesions surgically removed in our hospital between March 2016 and March 2018 were collected, and kits were used to measure the mRNA expression levels of DKK2, SPOCK1, proliferation genes and invasion genes. Results: DKK2, hyperplasia suppressor gene (HSG), p16, cell adhesion molecule-1 (CADM1), tissue inhibitor of matrix metalloproteinase 2 (TIMP2) and TIMP4 mRNA expression in bladder cancer lesions were significantly lower than those in paracancerous lesions while SPOCK1, β-catenin, CyclinD1, c-myc, Vimentin and matrix metalloproteinase 2 (MMP2) mRNA expression were significantly higher than those in paracancerous lesions;DKK2 was negatively correlated with β-catenin, CyclinD1, c-myc, Vimentin and MMP2, and positively correlated with HSG, p16, CADM1, TIMP2 and TIMP4;SPOCK1 was positively correlated with β-catenin, CyclinD1, c-myc, Vimentin and MMP2, and negatively correlated with HSG, p16, CADM1, TIMP2 and TIMP4. Conclusion: The low expression of oncogene DKK2 and the high expression of SPOCK1 in bladder cancer lesions are related to the changes of proliferation and invasion genes and may be involved in the growth of lesions.