GENE-RECOMBINANT HYDROGENOPHILUS BACTERIUM HAVING ENHANCED VALINE-PRODUCING ABILITY

摘要

A Hydrogenophilus bacterium in which a mutant acetolactase synthase III small subunit is formed which comprises a mutant amino acid sequence having any of the following amino acid substitutions (a) through (h) in the amino acid sequence of SEQ ID NO. 1: (a) substitution of Asn as amino acid No. 11 with Asp, His, or Ala; (b) substitution of Gly as amino acid No. 14 with Asp or Ala; (c) substitution of Ser as amino acid No. 17 with Phe; (d) substitution of Asn as amino acid No. 29 with Lys, Tyr, Asp, or His; (e) substitution of Thr s amino acid No. 34 with Ile; (f) substitution of Ala as amino acid No. 36 with Val; (g) deletion of Arg as amino acid No. 84 and all subsequent amino acids; and (h) substitution of Leu as amino acid No. 131 with Arg, is capable of efficiently producing valine using carbon dioxide as the only carbon source.