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BIOCONJUGATE VACCINES' SYNTHESIS IN PROKARYOTIC CELL LYSATES
BIOCONJUGATE VACCINES' SYNTHESIS IN PROKARYOTIC CELL LYSATES
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机译:生物共轭疫苗在原核细胞裂解液中的合成
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摘要
Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins, which may be utilized in vaccines, including anti- bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. Suitable carriers may include but are not limited to Haemophilus influenzae protein D (PD), Neisseria meningitidis porin protein (PorA), Corynebacterium diphtheriae toxin (CRM 197), Clostridium tetani toxin (TT), and Escherichia coli maltose binding protein, and variants thereof.
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