OPTICAL CAVITY SURFACE BIOCONJUGATION USING LIPID MEMBRANES FOR LABEL FREE, ULTRASENSITIVE DETECTION OF BIOMOLECULES

摘要

An optical system includes an optical resonant cavity, an optical source, an optical detector, and a signal processing circuit. The optical source is arranged to provide a source beam of light to be at least partially coupled into the optical resonant cavity. The optical detector is arranged to detect light from the source beam of light after the source beam of light has coupled into the optical resonant cavity to provide a detection signal. The signal processing circuit is configured to communicate with the optical detector to receive the detection signal. The optical resonant cavity has a bioconjugatable lipid membrane on a surface thereof. The bioconjugatable lipid membrane is functionalized to capture a specific biomolecule, and the signal processing circuit is further configured to determine a presence of the specific biomolecule when captured by the functionalized bioconjugatable lipid membrane based on processing the detection signal.