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ANTI-PERIPHERAL LYMPH NODE ADDRESSIN ANTIBODIES AND USES THEREOF
ANTI-PERIPHERAL LYMPH NODE ADDRESSIN ANTIBODIES AND USES THEREOF
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机译:外周前淋巴结肽抗体及其用途
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摘要
The present disclosure provides, inter alia, anti-peripheral lymph node addressin antibodies and antigen binding fragments thereof. The present disclosure also provides compositions comprising drug-containing polymeric particles that mimic lymphocyte migration in vivo and can specifically deliver immunosuppressive or immunoregulatory drugs to lymphoid tissues and sites of chronic inflammation where T-cell activation and T-cell mediated injury are occurring; such compositions comprise the antibodies or antigen-binding fragments thereof described in the disclosure. The present disclosure also comprises antibody-drug conjugates and compositions comprising the antibody-drug conjugates. Methods of preparing and using these antibodies, antigen-binding fragments thereof, and compositions thereof are also provided.
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