Polymeric nanoparticles improve antibody delivery to tumors and tumor draining lymph nodes to enhance cancer immunotherapy via checkpoint inhibition

摘要

We have demonstrated the ability to conjugate mAbs to lymphatic draining synthetic polymer NPs using a solvent- and denaturation-free disulfide displacement chemistry. NP conjugation enhances IgG accumulation within LNs draining the skin site of injection and lowers levels of IgG accumulation in off-target tissues. We have demonstrated the ability to reduce melanoma tumor growth using aCTLA4- & aPD1-NPs. These data suggest the potential of mAbs-NPs to increase the efficacy of checkpoint blockade for the treatment of advanced cancers through enhanced tumor retention and sentinel lymph node drug targeting.