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ATP-INDEPENDENT BIOLUMINESCENT REPORTER VARIANTS TO IMPROVE IN VIVO IMAGING

机译：ATP独立的生物发光报告变种可改善体内成像

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Provided herein are chemically modified luciferase substrates for spectrally shifted emission and enhanced water solubility. Provided herein are engineered luciferases. Moreover, provided herein are new ATP-independent bioluminescent reporters which have improved biochemical and photophysical properties and are expected to have broad applications. Finally, provided herein are spectral-resolved triple-color bioluminescent systems, suitable for flexible and convenient approaches to monitor multiple biological events in either qualitative or quantitative manners. 展开▼

机译：本文提供了化学修饰的荧光素酶底物，用于光谱移位的发射和增强的水溶性。本文提供了工程化的萤光素酶。此外，本文提供了新的不依赖ATP的生物发光报告分子，其具有改善的生化和光物理性质，并有望具有广泛的应用。最后，本文提供了光谱分辨的三色生物发光系统，其适合于以定性或定量方式监测多种生物事件的灵活方便的方法。展开▼

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公开/公告号WO2020176755A1

专利类型

公开/公告日2020-09-03

原文格式PDF

申请/专利权人 UNIVERSITY OF VIRGINIA PATENT FOUNDATION;
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申请/专利号WO2020US20144

发明设计人 AI HUI-WANG;YEH HSIEN-WEI;YING XIONG;
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申请日2020-02-27

分类号C12N9/02;C07D487/04;C12Q1/66;A61K49;

国家 WO

入库时间 2022-08-21 11:09:37

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