TOPOLOGICAL CONTROL OF RECEPTOR SIGNALING USING SYNTHETIC HOMO- AND HETERO-DIMERIC CYTOKINE MIMETICS

摘要

Disclosed herein are multimer-forming polypeptides that bind the erythropoietin receptor (EpoR) and thus can be used as designed ligands to topologically control EpoR receptor dimerization and induce differential effects in hematopoiesis, such as expanding red blood cells.