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PHARMACEUTICAL COMBINATION PREPARATION COMPRISING EZETIMIBE AND LOSARTAN
PHARMACEUTICAL COMBINATION PREPARATION COMPRISING EZETIMIBE AND LOSARTAN
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机译:包括依西替比和洛沙坦的药物组合制备
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摘要
The present invention relates to a pharmaceutical combination preparation comprising ezetimibe and losartan. When the pharmaceutical combination preparation is dissolved in a solution of pH 4.0 to 5.0, the amount of losartan dissolved within 10 minutes is 5,700 μg or less, and the amount of ezetimibe dissolved within 10 minutes is 270 μg or more. Dissolution in the solution of pH 4.0 to 5.0 is carried out under conditions of a temperature of 37℃ and a paddle speed of 50 rpm in 500 mL of an acetic acid buffer, according to the United States Pharmacopeia, for a pharmaceutical combination preparation comprising 20 mg of ezetimibe and 183 mg of losartan.
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