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PHARMACEUTICAL COMBINATION PREPARATION COMPRISING EZETIMIBE AND LOSARTAN
PHARMACEUTICAL COMBINATION PREPARATION COMPRISING EZETIMIBE AND LOSARTAN
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机译:包括依西替比和洛沙坦的药物组合制备
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摘要
The present invention relates to a pharmaceutical combination formulation comprising ezetimibe and losartan. In the pharmaceutical combination formulation, the amount of losartan eluted in 10 minutes when eluted in a solution of pH 4.0 to 5.0 is 5,700 μg or less, and the amount of eluted ezetimibe is 270 μg or more. Elution from the pH 4.0 to 5.0 solution was performed under the conditions of a paddle method at 37°C and 50 rpm in 500 mL of acetic acid buffer according to the US Pharmacopoeia for a pharmaceutical combination formulation containing 20 mg of ezetimibe and 183 mg of losartan. do.
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