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ARTIFICIAL ANTIGEN PRESENTING CELLS COMPRISING LIGANDS FOR NKG2D FOR EXPANDING IMMUNE CELLS FOR IMMUNOTHERAPY
ARTIFICIAL ANTIGEN PRESENTING CELLS COMPRISING LIGANDS FOR NKG2D FOR EXPANDING IMMUNE CELLS FOR IMMUNOTHERAPY
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机译:包含NKG2D的人工抗原提纯细胞,用于扩大免疫治疗的免疫细胞
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摘要
Disclosed herein are methods of expanding immune cells for immunotherapy and/or increasing the purity of a population of CAR T cells using artificial antigen presenting cells (aAPCs) having on their surface NKG2D ligand (such as for example MICA, MICB, RAET1E/ULBP4, RAET1G/ULBP5, RAET1 H/ULBP2, RAET1/ULBP1, RAET1UULBP6, and/or RAET1N/ULBP3 as well as mouse ligands H60, MULT-1, and Rae-1) and/or antibodies that bind NKG2D (including, but not limited to antibody fragments, such as, for example, F (ab')2, Fab', Fab, and/or scFv).
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