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BIPARATOPIC FR-ALPHA ANTIBODIES AND IMMUNOCONJUGATES

机译:双歧FR-α抗体和免疫缀合物

摘要

The present disclosure provides biparatopic antibodies comprising polypeptides that bind to folate receptor alpha (FRα) compositions comprising such biparatopic antibodies. In a specific aspect, the biparatopic antibodies bind to FRα and modulate FRα activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a biparatopic antibody that specifically binds to FRα and modulates FRα activity.
机译:本公开提供了双互补位抗体,其包含与叶酸受体α(FRα)组合物结合的多肽,所述叶酸受体α(FRα)组合物包含此类双互补位抗体。在一个具体方面,双互补位抗体结合FRα并调节FRα活性。本公开还提供了通过施用特异性结合FRα并调节FRα活性的双互补位抗体来治疗疾病例如癌症的方法。

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