Method of producing injectable adhesive composition for fixing bone grafting materials and a injectable adhesive composition for fixing bone grafting materials produced thereby

摘要

The present invention relates to a method for preparing an implantable adhesive composition for fixation of bone graft material for fixing a bone graft material or a shielding membrane filled in the body for restoration of a defect of bone tissue, and to an implantable adhesive composition for fixation of bone graft material prepared through the same. The decellularized extracellular matrix may be prepared by preparing an injectable adhesive composition for fixing bone grafts including a decellularized extracellular matrix (dECM) having excellent biocompatibility and a calcium phosphate compound similar to bone tissue and an inorganic component. Protein components, such as collagen, cause gelation reaction at a temperature similar to body temperature, and can be used to fix bone grafts and shielding membranes through physical fibrosis when inserted into the body. Absorbed, no secondary removal procedure is required. In addition, by using the decellularized extracellular matrix as an adhesive material, the heterologous cells are completely removed and the immune rejection reaction is significantly lowered to the operator, as well as collagen, glycoprotein, and BMP-2 in the decellularized extracellular matrix. Contains bone-derived proteins that can help bone formation, such as ALP, has excellent bone conduction and osteoinduction.