Compositions for inhibiting myogenic differentiation drug screening system and screening methods for treating muscle wasting

摘要

The composition of the present invention can implement the muscle wasting disease model in vitro by inhibiting the differentiation of myoblasts, it can be used for screening for muscle wasting disease therapeutics. In addition, the composition was confirmed to upregulate or down-regulate genes of TNF-α and WNT signaling systems known to be involved in muscle formation and regeneration, muscle killing and degeneration in cells with differentiation inhibition. Candidates that regulate delivery systems can be used to develop therapeutics for muscle wasting diseases.