A composition for detecting hydrogen sulfide and composition for diagnosing or imaging imflammation hypoxic-damaged tissue or cancer in vivo containing the same as an active ingredient

摘要

The present invention relates to a composition for hydrogen sulfide detection or concentration measurement, and to a composition for diagnosing or imaging in vivo inflammation, hypoxic damaged tissues, or cancer, which contains the composition as an active ingredient. The hydrogen sulfide detection or concentration measurement composition (^(99m)Tc-alpha-hydroxy acid), comprising a compound represented by chemical formula 1: O = ^(99m)Tc(O = CO^--CHO^--(CHR^1)_m-CH_2R^2)_2, with ^(99m)Tc labeled with alpha-hydroxy acid, is capable of detecting hydrogen sulfide and measuring the concentration at in vitro or at a level of in vivo. Accordingly, the composition for hydrogen sulfide detection or concentration measurement of the present invention: can be useful to detect hydrogen sulfide and measure the concentration thereof and to further reveal the biological role of hydrogen sulfide in a human body and can be useful for the hydrogen sulfide detection, imaging, and concentration measurement of hypoxic tissues or diseases selected from a group consisting of angiogenesis, inflammation, cancer, Alzheimer′s dementia, cardiovascular ischemia, and cerebrovascular ischemia.