Radiomix-based imaging tool for monitoring tumor-lymphocyte infiltration and outcome in cancer patients treated with anti-PD-1 / PD-L1

摘要

The present invention proposes a radiomix based biomarker for detecting the presence and density of tumor infiltrating CD8 T cells in a solid tumor, without using any biopsy of the tumor. The present invention also proposes using this information to evaluate the immune phenotype of the solid tumor. In certain embodiments, the present invention proposes predicting the survival and / or therapeutic efficiency of cancer patients treated with immunotherapy, such as anti-PD-1 / PD-L1 monotherapy.