Compositions, methods and uses of recombinant nucleic acids for eliciting Th1-biased or Th2-biased immune responses in a subject are provided. In some embodiments, the nucleic acid comprises a first nucleic acid segment encoding an MHC-II transport signal, and a second nucleic acid segment encoding a polytope peptide and a Th1 specific polarization epitope or a Th2 specific polarization epitope. Optionally, the Th1 specific polarization epitope or Th2 specific polarization epitope is part of a polytope peptide. The recombinant nucleic acid can be inserted into a viral, bacterial or yeast expression vector such that the recombinant protein encoded by the recombinant nucleic acid is expressed in the individual's antigen-presenting cells to elicit a Th1-biased or Th2-biased immune response in the individual. .
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