Lefty A Fusion Protein Comprising Human Lefty A Protein Variants And Use Thereof

摘要

The present invention relates to a human Lefty A protein variant having improved productivity and stability, a fusion protein comprising the protein variant, and a composition for preventing and/or treating neuromuscular disease comprising the protein variant or fusion protein. The present invention improves the expression level and production yield in animal cells based on superior stability than the naturally occurring human Lefty A protein by producing a human Lefty A protein variant and a fusion protein containing the variant. In addition, the administration of the produced Human Lefty A protein variant or fusion protein can restore the neurological function and motor function of the neurological disease model animal. It can be effectively prevented or treated.