1 Fc- Type 1 interferon neutralizing Fc-fusion proteins and uses thereof

摘要

The present invention relates to a type 1 interferon-neutralizing Fc-fusion protein and uses thereof, and more specifically, a dimer-type polypeptide having a monomer comprising an interferon receptor fragment or an antibody Fc fragment, and a method for preparing the same, It relates to a pharmaceutical composition comprising the same. The type 1 interferon-neutralizing Fc-fusion protein of the present invention blocks the binding between the type 1 interferon and the interferon receptor, and has excellent ability to inhibit the signaling and biological activity of the interferon, thereby effectively treating diseases mediated by the type 1 interferon.