Recombinant immunotoxin targeting carcinoembryonic antigen and pharmaceutical composition for preventing or treating cancer comprising the same

摘要

The present invention relates to a recombinant immunotoxin targeting a cancer antigen and a pharmaceutical composition for preventing or treating cancer comprising the same, and more specifically, a base sequence encoding an antibody or fragment thereof specifically binding to the cancer antigen and a pseudomonas exotoxin A nucleic acid molecule comprising a nucleotide sequence encoding A (PEA), a recombinant expression vector containing the nucleic acid molecule, a host cell transformed with the recombinant expression vector, specifically binding to a cancer antigen using the recombinant expression vector Method for producing a recombinant immunotoxin to which an antibody and pseudomonas exotoxin A are bound, to a pharmaceutical composition for the prevention or treatment of cancer overexpressing a cancer immunogen containing the recombinant immunotoxin and the recombinant immunotoxin for killing cancer cells overexpressing the cancer antigen It is about.