Small molecule inhibitors of covalent epitope-caleticulin interactions and methods of use

摘要

The present invention relates to the field of pharmaceutical chemistry. In particular, the present invention is a new class of small molecules having a triazole-methyl-piperidinyl-pyrroliyl-propenone structure that functions as a modulator of covalent epitope (SE)-caleticulin (CRT) binding and/or interaction. And immunomodulatory disorders (e.g., autoimmune diseases, inflammatory diseases (e.g., autoimmune diseases, inflammatory diseases) by selectively inhibiting SE-CRT interaction and/or signaling pathways that are generally irritable or difficult to control in arthritis and/or other diseases or conditions. For example, chronic inflammatory disease), and bone erosion disease).