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CD40L TN3 CD40L-SPECIFIC TN3-DERIVED SCAFFOLDS AND METHODS OF USE THEREOF

机译：CD40L TN3 CD40L特定TN3衍生的脚手架及其使用方法

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摘要

The present invention provides a tenasin FnIII domain-based scaffold that specifically binds CD40L. The present invention also provides engineered variants with increased affinity for the target. The invention also relates to engineered scaffolds as prophylactic, diagnostic or therapeutic agents, particularly for therapeutic use in SLE and other autoimmune diseases and conditions.

机译：本发明提供了特异性结合CD40L的基于肌腱蛋白FnIII结构域的支架。本发明还提供了对靶标具有增加的亲和力的工程变体。本发明还涉及经工程改造的支架作为预防，诊断或治疗剂，特别是用于SLE和其他自身免疫性疾病和病症的治疗。

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公开/公告号KR20200085376A

专利类型
公开/公告日2020-07-14

原文格式PDF
申请/专利权人 메디뮨 엘엘씨;
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申请/专利号KR20207019515
发明设计人 코일 앤서니;바카 마뉴엘;디스테드 토마스;드라빅 스테이시;그린버그 루바;노바라 사바츠;오가네샨 바헤;허브스트 로날드;스펜서 데이비드 케네스;
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申请日2012-10-10
分类号C07K14/78;A61K38/39;A61P1/04;A61P1/16;A61P17/06;A61P17/14;C07K16/28;
国家 KR
入库时间 2022-08-21 11:06:26

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