Fabrication of Novel Scaffolds Containing Collagen-I/Polylactic Acid/Nanohydroxyapatite via Co-electrospinning Methods

摘要

A novel scaffold containing collagen-Ⅰ/polylactic acid(PLA)/nanohydroxyapatite(nHA) was prepared via co-electrospinning method.Different target substrates were used to improve the collection efficiency of this scaffold. The properties of the novel scaffold were compared with those of conventionally prepared ones.Compared to conventional method,the modified method was more efficient in producing the scaffold.Moreover,the porosity,thickness, and morphology of the novel scaffold were better than those of scaffolds prepared by conventional methods. The properties of collagen-Ⅰ,collagen-Ⅰ/PLA and collagen-Ⅰ/PLA/nHA scaffolds were also compared.Diameters of the electrospun fibers ranged from 180 to 405 nm,and roughness was present on the surface of the fibers due to the deposition of crystals of nHA along the long axis of the fibers.The fibers of the collagen-Ⅰ/PLA/nHA scaffold and the fibers of natural bone tissue had similar structure.