EVALUATION METHOD FOR NEUROPSYCHIATRIC DRUG EFFICACY BY BRAIN MICRODIALYSIS AND SIMULTANEOUS DETERMINATION OF MULTIPLE NEUROTRANSMITTERS IN NONHUMAN PRIMATES

摘要

The present invention applies microdialysis to the study of primates to simultaneously collect and analyze neurotransmitters and their metabolites from specific target tissues of the brain to analyze the control algorithm, and based on this, the effectiveness of the treatment for neuropsychiatric diseases and It relates to an evaluation technology developed as a data platform that can predict safety and drug interactions. When the analysis method according to the present invention is used, it is possible to simultaneously analyze neurotransmitters in body fluids collected by microdialysis from brain tissue, and can be utilized in the development of therapeutic agents for neuropsychiatric diseases.