Treatment of idiopathic thrombocytopenia purpura (ITP) using Romiflostim

摘要

The present invention relates to a method of treating ITP in a patient with idiopathic thrombocytopenia purpura (ITP), the method comprising the steps of: (a) administering romiflostim to the patient on a weekly basis; (b) increasing the weekly dose until a platelet level of at least about 50 to 200×10 ⁹ /L is reached; (c) if the platelet count is maintained above 200×10 ⁹ /L for two consecutive weeks, reducing the weekly dose of the Romiflostim; (d) If the weekly dose is 1 μg/kg, the platelet level is maintained at 200×10 ⁹ /ℓ or higher for 2 consecutive weeks, or if the platelet level is 400×10 ⁹ /ℓ or more, Romiflosteam is stopped. Step to do; And (e) if the platelet level reaches 200×10 ⁹ /L or more within the first 4 to 12 weeks of treatment, maintaining an untreated period of at least about 24 weeks, and not providing Romiflosteam to the patient during that period. Includes.