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miR-1260b A composition comprising microRNA-1260b inhibitors for inhibiting the proliferation migration or invasion of breast cancer cell

机译：miR-1260b包含用于抑制乳腺癌细胞增殖迁移或侵袭的microRNA-1260b抑制剂的组合物

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摘要

The present invention relates to a pharmaceutical composition for inhibiting proliferation, migration, or invasion of breast cancer cells comprising a microRNA-1260b inhibitor, microRNA-1260b inhibits the expression of CASP 8 of apoptosis to prevent proliferation, migration and invasion of breast cancer cells. It can be used to inhibit and prevent, treat or predict the prognosis of abnormal proliferation, migration or invasion of breast cancer cells.

机译：本发明涉及用于抑制乳腺癌细胞增殖，迁移或侵袭的药物组合物，其包含microRNA-1260b抑制剂，microRNA-1260b抑制细胞凋亡的 CASP 8的表达以防止增殖，迁移。和侵袭乳腺癌细胞。它可以用于抑制和预防，治疗或预测乳腺癌细胞异常增殖，迁移或侵袭的预后。 展开▼

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公开/公告号KR20200109623A

专利类型

公开/公告日2020-09-23

原文格式PDF

申请/专利权人 연세대학교 원주산학협력단;
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申请/专利号KR20190028913

发明设计人 이혜영;김정호;안성우;박선영;김지혁;김승일;
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申请日2019-03-13

分类号A61K48;A23L33/13;A61P35;

国家 KR

入库时间 2022-08-21 11:06:01

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1. 一种抑制三阴性乳腺癌细胞增殖和迁移的药物组合物及其应用 [P] . 中国专利： CN113855664A . 2021-12-31

2. 细胞增殖抑制蛋白质、多核苷酸、与多核苷酸对应的反义核苷酸,以及细胞增殖抑制剂、癌症诊断试剂、癌症治疗剂和用于基因治疗的组合物 [P] . 中国专利： CN1402784A . 2003-03-12

3. DNA was isolated and purified, peptu00ecdeo, sequences of amino acids of human and murine sphk2, construction of recombinant DNA, host cell.Methods for producing a peptu00ecdeo of sphingosine kinase type 2 isoform of mouse and human.And to detect an agent or a drug that inhibits or promotes the activity of sphingosine kinase type 2, agent or product, methods for regulating a biological process in a mamu00ecfero,For the treatment or the improvement of a disease resulting from cell death increased or reduced cell proliferation.For the treatment or management of a disease resulting from reduced cell death or cell proliferation increased.And for the treatment or the improvement of a disease resulting from abnormal migration or motility of cells selected from the group consisted of cancer, restenose and diabetic neuropathy.Composition for the treatment or the improvement of UIMA disease resulting from cell death increased or reduced cell proliferation.Methods for screening for agents or [P] . BR0109827A . 2004-07-06

机译：分离纯化DNA，肽，人和鼠sphk2的氨基酸序列，重组DNA的构建，宿主细胞。小鼠和人2型鞘氨醇激酶2型亚型的肽的制备方法，并检测抑制或促进2型鞘氨醇激酶活性的药物或药物，药物或产物的调节方法，用于治疗哺乳动物的生物学过程的方法，用于治疗或改善由细胞死亡引起的疾病的方法，增加或减少的细胞增殖用于治疗或管理由减少的细胞死亡或细胞增殖引起的疾病，以及用于治疗或改善由癌症，再狭窄和糖尿病性神经病变组成的组中的细胞异常迁移或运动导致的疾病。用于治疗或改善由细胞死亡引起的UIMA疾病的组合物可增加或减少细胞增殖。

4. COMPOSITION FOR INHIBITING CANCER CELL PROLIFERATION, ANTI-CANCER COMPOSITION, COMPOSITION FOR INHIBITING CANCERIZATION OF NORMAL CELLS, COMPOSITION FOR INHIBITING CANCER ONSET AND COMPOSITION FOR INDUCING CANCER CELL DEATH [P] . 世界知识产权组织专利： WO2019221003A1 . 2019-11-21

机译：抑制癌细胞增殖的组合物，抗癌组合物，抑制正常细胞癌化的组合物，抑制癌症发作的组合物和诱导癌细胞死亡的组合物

5. method for inhibiting the growth, migration, proliferation and / or metastasis of a precancerous, cancerous or neoplastic cell or inhibiting a pathogen, topical probiotic composition, bandage or dressing, method of treating skin damage due to UV radiation and pharmaceutical composition [P] . BR112019017962A2 . 2020-05-19

机译：抑制癌前，癌细胞或赘生性细胞的生长，迁移，增殖和/或转移或抑制病原体的方法，局部益生菌组合物，绷带或敷料，治疗由于紫外线辐射引起的皮肤损伤的方法和药物组合物

1. Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways [J] . Wenzhong Zhou, Gengshen Yin, Zhongbing Ma, 中国癌症研究（英文版） . 2020,第003期

2. Silencing Filamin A Inhibits the Invasion and Migration of Breast Cancer Cells by Up-regulating 14-3-3σ [J] . Zhi-min JI, Li-li YANG, Juan NI, 当代医学科学(英文) . 2018,第003期

3. Long noncoding RNA STXBP5‐AS1 inhibits cell proliferation, migration, and invasion via preventing the PI3K/AKT against STXBP5 expression in non–small‐cell lung carcinoma Long noncoding RNA STXBP5‐AS1 inhibits cell proliferation, migration, and invasion via preventing the PI3K/AKT against STXBP5 expression in non–small‐cell lung carcinoma [J] . Huang Jingyu, Xie Nianlin, Huang Hu, Journal of cellular biochemistry. . 2019,第5期

4. Long non-coding RNA BRE-AS1 inhibits the proliferation, migration, and invasion of cancer cells in triple-negative breast cancer and predicts patients’ survival by downregulating miR-21 [J] . Gao Jianchao, Wang Sisi, Zhang Zhisheng, BMC Cancer . 2021,第1期

5. Ailanthone exerts anticancer effect by up-regulating miR-148a expression in MDA-MB-231 breast cancer cells and inhibiting proliferation, migration and invasion [J] . Gao Wei, Ge Shuke, Sun Jiayi Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2019,第期

6. Research on Mechanism of FGFR1 Inhibitor BAY1163877 against Proliferation of Breast Cancer Cells [C] . Yingnan Cui, Li Zhang, Jin Xing Annual International Conference on Materials Science and Engineering . 2019

7. The Role of aPKCs and aPKC Inhibitors in Cell Proliferation and Invasion in Breast and Ovarian Cancer [D] . Smalley, Tracess B. 2020

8. Norstictic Acid Inhibits Breast Cancer Cell Proliferation Migration Invasion and In Vivo Invasive Growth Through Targeting C-Met [O] . Hassan Y. Ebrahim, Heba E. Elsayed, Mohamed M. Mohyeldin, -1

9. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart [O] . V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

1. miRNA-195:The New Target of Inhibiting the Proliferation,Migration and Invasion of Gastric Cancer Cells via Propofol [J] . Yuming Zhang ,Zhijun Mao ,Fei Xue . 抗癌研究 . 2021,第002期

2. Silencing Filamin A Inhibits the Invasion and Migration of Breast Cancer Cells by Up-regulating 14-3-3σ [J] . Zhi-min JI ,Li-li YANG ,Juan NI . 华中科技大学学报（医学）（英德文版） . 2018,第003期

3. Effect of Pin1 Inhibitor Juglone on Proliferation, Migration and Angiogenic Ability of Breast Cancer Cell Line MCF7Adr [J] . Yuan-gui HU ,Yun-feng SHEN ,Yi LI . 华中科技大学学报（医学）（英德文版） . 2015,第004期

4. 磷酸二酯酶4抑制剂对乳腺癌细胞增殖迁移影响的研究 [C] . 刘超 ,刘爵 ,陈武 . 第十一届北京畜牧兽医青年科技工作者“新思想新观点新方法”论坛 . 2015

5. Ⅳ型胶原酶抑制剂的筛选及活性研究第一部分间接ELISA法Ⅳ型胶原酶抑制剂筛选模型的应用及荧光底物法Ⅳ型胶原酶抑制剂筛选模型的建立;第二部分 H25抑制HT1080细胞增殖和侵袭转移活性的体外评价及抗侵袭作用机理的初步探讨;第三部分微生物多糖1519A和3748A的分离 [A] . 贺晓波 . 2005