Synthesis method of coumarin derivatives from extract Angelica gigas Nakai

摘要

DN (Decursin) and DA (Decursinol angelate) are known to be effective in anti-cancer, anti-inflammatory and fatty liver, but studies on the pharmacological efficacy of a single substance of DN or DA on alcohol-induced fatty liver have not been conducted. In the present invention, the present invention was completed by confirming the function of protecting liver (干) of these DNs and DAs, and by confirming a method for simply synthesizing them through continuous research and development for DN and DA. That is, the compound of Structural Formula (1) and the NN-dimethylamino pyridine compound of Structural Formula 4, which is a reaction accelerator, were dissolved in CH ₂ Cl ₂ and reacted at 0° C. for 24 hours in the presence of nitrogen (N _2), It relates to the invention of a method for preparing the compound of 2) and for preparing the compound of the structural formula (3) by reacting the compound of the structural formula (1) and the compound of the structural formula (5).