PROTECTANT AGAINST NEURONAL CELL DEATH BY OXIDATIVE STRESS COMPRISING L-SERINE AND THE ROOT EXTRACT OF ANGELICA GIGAS AS AN EFFECTIVE COMPONENT

摘要

The present invention relates to a composition for inhibiting neuronal cell death containing L-serine and Angelicae extract as an active ingredient, and more particularly, by using L-serine and Angelicae extract together to minimize the use of expensive Angelicae extract and excellent It relates to a pharmaceutical composition for preventing or treating degenerative neurological diseases exhibiting neuronal cell death inhibitory activity, and a health functional food prepared by adding a component to improve sensory properties to the active ingredient. L-serine and Angelicae extract as active ingredients of the composition for inhibiting neuronal cell death of the present invention have excellent efficacy in inhibiting apoptosis due to oxidative stress of neurons, as demonstrated through the examples of the present specification. And, while minimizing the use of expensive Angelica Angelica extract powder, it exhibits excellent neuronal cell death inhibitory effect. In addition, there is a feature that continuous intake is possible by preparing a mixed powder having excellent sensory properties by mixing a certain amount of subsidiary materials of a sweetener, acidulant, and flavoring agent with L-serine and angelica powder, which is difficult to ingest due to low organoleptic properties alone. The composition for inhibiting neuronal cell death of the present invention does not have hemolytic activity on human red blood cells, has excellent thermal stability, and does not show any loss of neuronal cell death inhibitory effect even in acidic conditions of pH 2, so It is a very useful invention to be used for a purpose.