A method for inducing transdifferentiation of cardiomyocytes based on exosome

摘要

The present invention relates to a method for inducing cardiomyocyte cross-differentiation based on exosomes, and more specifically, separating exosomes from a culture medium in the process of differentiating stem cells into cardiomyocytes; Culturing fibroblasts in the cardiomyocyte reprogramming culture medium comprising the isolated exosomes; And culturing the fibroblasts cultured in the cardiomyocyte reprogramming culture in a cardiomyocyte-derived culture medium containing the exosomes, the method of cross-differentiation from fibroblasts to cardiomyocytes.