APP BACE ASBI APP SPECIFIC BACE INHIBITORSASBIsAND USES THEREOF

摘要

In certain embodiments, APP-specific BACE inhibitors (ASBIs) and uses thereof are provided. In certain embodiments, prevent or delay the onset of pre-Alzheimer's condition and / or cognitive dysfunction, ameliorate one or more symptoms of pre-Alzheimer's condition and / or cognitive dysfunction, or pre-Alzheimer's condition or Methods are provided for preventing or delaying the progression of cognitive dysfunction to Alzheimer's disease, wherein the method prevents or delays the onset of pre-Alzheimer's cognitive dysfunction in a subject in need thereof with an APP specific BACE inhibitor (ASBI). And / or in an amount sufficient to ameliorate one or more symptoms of pre-Alzheimer's cognitive dysfunction, and / or to prevent or delay the progression of pre-Alzheimer's state or cognitive dysfunction to Alzheimer's disease. . In certain embodiments, the ASBI is a flavonoid (eg galangin) or a flavonoid prodrug (eg a galangin prodrug).