HUMAN TRANSFORMED CHONDROCYTE CELL LINE-BASED DRUG SCREENING SYSTEM FOR CARTILAGE DISEASES

摘要

The present invention relates to a recombinant expression vector for cartilage disease drug screening, a cell line transformed by the expression vector, and a method for screening a drug effective in treating cartilage diseases by using the same, wherein since all the components forming the expression vector are human-derived genetic factors, novel drugs screened thereby are deemed to be more effective in the treatment of cartilage diseases in human. Further, since the present invention enables to determine whether or not cartilage diseases of a gene of an unknown function are treatable, through additional transformations, the present invention enables comparisons of various drugs in terms of a cartilage disease treatment function, and is also expected to enable evaluations on optimal treatment concentrations and indirect cytotoxicity. Finally, a novel substance having cartilage regeneration efficacy discovered through a screening system according to the present invention, 2-anthraquinonecarboxylic acid, is promising to be applicable to the treatment of various cartilage diseases.;COPYRIGHT KIPO 2020