B c-FLIP A use of c-FLIP protein in Hepatitis B virus

摘要

The present invention relates to the role of c-FLIP in HBV replication. According to the present invention, the DED2 region of c-FLIP interacts with HBx, and the DED1 region protects HBx from being degraded by ubiquitin to replicate HBV. The mechanism of action was found. In addition, the present invention confirmed that c-FLIP increases the expression of hepatocyte nuclear factor (HNF) 1α and / or HNF3β involved in HBV activity, promotes HNF4α transcription, and replicates HBV. Accordingly, the present invention provides a new mechanism of action of c-FLIP to express HBV replication in hepatocytes.