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Selective c-FLIP inhibitors as anticancer agents
Selective c-FLIP inhibitors as anticancer agents
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机译:选择性c-FLIP抑制剂作为抗癌药
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摘要
The present invention provides nine selective c-FLIP inhibitors that are useful for treating cancer, alone or in combination with other chemotherapeutic agents, particularly TRAIL-based chemotherapeutic agents. The invention also relates to pharmaceutical compositions and kits comprising at least one of the nine selective c-FLIP inhibitors, and methods of treating cancer, specifically overcoming chemoresistance or TRAIL-based It also relates to its use in a method for improving the sensitivity of a tumor to treatment.
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