The present invention relates to a SIRT 1 activator and a medical use thereof, and in the present invention, a novel SIRT 1 activator compound based on the benzo [d] furan skeleton, its crystalline form, its hydrate or salt thereof was prepared, and the compound The effects of improving obesity, insulin resistance and dyslipidemia, fatty liver improvement effect, cell aging protection, oxidative stress protection, and prolonged lifespan of yeast were confirmed. Therefore, the novel SIRT 1 activator compound having the above-described effect is for preventing metabolic diseases including obesity, diabetes, dyslipidemia, liver disease including alcoholic or non-alcoholic fatty liver, hepatitis, or the like. It can be usefully used as a therapeutic pharmaceutical composition, a health food composition for improving cell aging or prolonging life.
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