8-O- Antidiabetic and antioxidant compositions comprising Flavonoid 8-O-glucuronide compounds

摘要

The invention containing the novel compounds derived from one member mallow, flavonoids 8- O - A pharmaceutical composition having, anti-diabetic and antioxidant activity, including Need (Flavonoid 8- O -glucuronide) compound with glucuronic as an active ingredient, It relates to a food composition. In the present invention, it was confirmed that the damaged pancreas in the zebrafish diabetes model induced by alloxane by the compound derived from the mallow fraction exhibits anti-diabetic effect through a mechanism of restoring ability and K _ATP channel. In addition, all flavonoid 8- O -glucuronide compounds isolated from mallow have excellent antioxidant activity in ABTS, ORAC, and SOD analysis, thereby causing the glucuronic acid moiety bound to position 8 of the flavonoid to be attributed to the antioxidant activity expression. It was confirmed. Therefore, the composition of the present invention may be widely used in the development of anti-diabetic and antioxidant compositions and health functional foods.