Universal influenza vaccine using cold-adapted live-attenuated virus

摘要

The present invention relates to a universal influenza vaccine using a low temperature adapted live attenuated vaccine, and more particularly, the present invention relates to a universal influenza vaccine composition comprising at least one low temperature adapted live attenuated vaccine and a flu vaccination method using the same. . The present invention, the universal flu live vaccine composition exhibits a cross-defense effect against a wide variety of flu viruses, and can guarantee a strong defense efficacy, a wide defense range, and safety that were not expected in the conventional HA vaccine. In addition, by inducing various immunological effects, the method for inoculating a heterologous vaccine of the present invention is expected to significantly increase cross-immunogenicity and cross-defense ability and thus can be usefully utilized as a method for preventing universal flu. In addition, according to the live vaccine inoculation method of the present invention, since a person who already has basal immunity through infection of the flu virus or vaccination with flu may already be considered to be in the first vaccination state, one live vaccine inoculation (additional vaccination) It is possible to expect a wide range of protective effects against various viruses by inducing the enhancement of the cross-immune response.